TSH crosslinks to the TSH receptor through the β subunit

Buckland, Paul Robert, Strickland, Thomas W., Pierce, John G. and Rees Smith, Bernard 1985. TSH crosslinks to the TSH receptor through the β subunit. Endocrinology 116 (5) , pp. 2122-2125. 10.1210/endo-116-5-2122

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Abstract

TSH binds specifically to the TSH receptor present on the surface of thyroid follicular cells and consequently activates adenylate cyclase. It was not known, however, which of the two subunits of the TSH bound to the receptor. By covalently crosslinking TSH to its receptor and characterizing the product with antisera specific for either the a or B subunit of TSH, we have shown that the TSHB subunit but not the TSHa subunit crosslinks to the TSH receptor.

Item Type:	Article
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Endocrine Society
ISSN:	0013-7227
Last Modified:	05 Feb 2020 03:36
URI:	https://orca.cardiff.ac.uk/id/eprint/57471

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