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A regioselective multicomponent protocol for the synthesis of novel bioactive 4-hydroxyquinolin-2(1H)-one grafted monospiropyrrolidine and thiapyrrolizidine hybrids

Sankaran, Mathan, Uvarani, Chokkalingam, Chandraprakash, Kumarasamy, Lekshmi, Swathi U., Suparna, Sengupta, Platts, James Alexis and Mohan, Palathurai Subramaniam 2014. A regioselective multicomponent protocol for the synthesis of novel bioactive 4-hydroxyquinolin-2(1H)-one grafted monospiropyrrolidine and thiapyrrolizidine hybrids. Molecular Diversity 18 (2) , pp. 269-283. 10.1007/s11030-013-9498-y

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Abstract

An expedient route toward the synthesis of 4-hydroxyquinolone grafted spiropyrrolidines or pyrrolizidines has been accomplished through 1,3-dipolar cycloaddition reaction of various azomethine ylides derived from isatin or acenaphthalene and sarcosine with 4-hydroxyquinolone derivatives as dipolarophile. The regio and stereo chemical outcome of the cycloaddition reaction is ascertained by X-ray crystallographic studies and spectroscopic techniques of the cycloadducts. Furthermore, cytotoxicity evaluation of selected compounds showed significant inhibition of cell proliferation against cervical as well as colon cancer cell lines.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Springer
ISSN: 1381-1991
Last Modified: 18 Feb 2019 10:51
URI: http://orca-mwe.cf.ac.uk/id/eprint/57293

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