Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Epstein-Barr virus regulates STAT1 through latent membrane protein 1

Richardson, Ciaran Joseph, Fielding, Ceri, Rowe, Martin and Brennan, Paul 2003. Epstein-Barr virus regulates STAT1 through latent membrane protein 1. Journal of Virology 77 (7) , pp. 4439-4443. 10.1128/JVI.77.7.4439-4443.2003

Full text not available from this repository.

Abstract

This study shows a mechanism for the increase of signal transducer and activator of transcription 1 (STAT1) in Epstein-Barr virus-immortalized cells. Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity. LMP-1-expressing cells can induce an increase in STAT1 expression in LMP-negative cells in the same culture, suggesting an indirect regulation of STAT1 expression. The increase in STAT1 expression is mediated by the C-terminal activating region 1 (CTAR-1) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IκB, demonstrating a role for NFκB in LMP-1-mediated STAT1 expression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR355 Virology
Publisher: American Society for Microbiology
ISSN: 0022-538X
Last Modified: 10 Oct 2017 15:33
URI: http://orca-mwe.cf.ac.uk/id/eprint/57195

Citation Data

Cited 32 times in Google Scholar. View in Google Scholar

Cited 19 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item