Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Susceptibility of B lymphocytes to adenovirus type 5 infection is dependent upon both coxsackie-adenovirus receptor and αvβ5 integrin expression

Richardson, Ciaran Joseph, Brennan, Paul, Powell, Martin B., Prince, Stuart N., Chen, Yun-Hsiang, Spiller, O. Brad and Rowe, Martin 2005. Susceptibility of B lymphocytes to adenovirus type 5 infection is dependent upon both coxsackie-adenovirus receptor and αvβ5 integrin expression. Journal of General Virology 86 (6) , pp. 1669-1679. 10.1099/vir.0.80806-0

Full text not available from this repository.

Abstract

Human lymphocytes are resistant to genetic modification, particularly from recombinant adenoviruses, thus hampering the analysis of gene function using adenoviral vectors. This study engineered an Epstein–Barr virus-transformed B-lymphoblastoid cell line permissive to adenovirus infection and elucidated key roles for both the coxsackie–adenovirus receptor and αvβ5 integrin in mediating entry of adenoviruses into these cells. The work identified a strategy for engineering B cells to become susceptible to adenovirus infection and showed that such a strategy could be useful for the introduction of genes to alter lymphoblastoid-cell gene expression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR355 Virology
Publisher: Society for General Microbiology
ISSN: 0022-1317
Last Modified: 17 Mar 2018 20:46
URI: http://orca-mwe.cf.ac.uk/id/eprint/57192

Citation Data

Cited 10 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item