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Antigen presentation by dendritic cells is NF kappa B dependent in vitro and in vivo [abstract]

Bondeson, Jan, Yoshimura, Satomichi, Calder, Virginia, Brennan, Fionula M., Foxwell, Brian M. J. and Feldmann, Marc 2001. Antigen presentation by dendritic cells is NF kappa B dependent in vitro and in vivo [abstract]. Arthritis & Rheumatism 44 (9) , S213. 10.1002/1529-0131(200109)44:9+<::AID-ART426>3.0.CO;2-7/abstract

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Abstract

Antigen presentation is a key rate-limiting step in the immune response. Dendritic cells (DCs) have been reported to be the most potent antigen-presenting cells for naïve T cells, but little is known about the biochemical pathways that regulate this function. We here demonstrate that mature murine DC can be infected with adenovirus at high efficiency (>95%) and that an adenovirus transferring the endogenous inhibitor IkappaBalpha blocks nuclear factor-kappa B (NF-kappaB) function in murine DC. This result indicates that antigen presentation in the mixed leucocyte reaction is NF-kappaB dependent, confirming data with human DC in vitro. However, the importance of this finding depends on verifying that this is true also in vivo. Using delayed type hypersensitivity with allogeneic cells, we show that NF-kappaB inhibition had a marked ...

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Additional Information: 2001 Annual Scientific Meeting Abstracts, November 10–15, 2001, San Francisco, CA.
Publisher: John Wiley & Sons
ISSN: 0004-3591
Last Modified: 30 Jun 2017 03:25
URI: http://orca-mwe.cf.ac.uk/id/eprint/57124

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