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Chopping and changing: long-term results of epilepsy surgery

Sadek, Ahmed-Ramadan and Gray, William Peter 2011. Chopping and changing: long-term results of epilepsy surgery. The Lancet 378 (9800) , pp. 1360-1362. 10.1016/S0140-6736(11)61593-6

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Abstract

Surgical management of medically refractory focal epilepsy has seen a resurgence in the past 20 years.1 Advances in structural and functional neuroimaging2 and invasive electroencephalography have increased success in identifying the ictal onset zone; and functional MRI, tractography, and cortical mapping have allowed for safe resection. Seizure freedom is the most substantial predictor of improved quality of life, and freedom rates of 60–70% are routinely reported after 1–2 years' follow-up.3, 4 and 5 However, seizure control at late follow-up is less good (table) with many studies reporting seizure freedom rates of 40–50% at 10 years. Moreover, few studies show how many patients have sustained long-term seizure freedom after surgery. Importantly, although patients who are seizure free at 2 years are likely to remain so at 7 years6 and 10 years,7 late seizure recurrence is not uncommon and little is known about its prediction, prognosis, management, or causation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RD Surgery
Publisher: Elsevier
ISSN: 0140-6736
Last Modified: 04 Jun 2017 06:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/57117

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