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Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus

Howell, Owain W., Silva, Sharmalene, Scharfman, Helen E., Sosunov, Alexander A., Zaben, Malik J. A., Shtaya, Anan, Mckhann II, Guy, Herzog, Herbert, Laskowski, Alexandra and Gray, William Peter 2007. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiology of Disease 26 (1) , pp. 174-188. /10.1016/j.nbd.2006.12.014

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Abstract

We have shown that neuropeptide Y (NPY) regulates neurogenesis in the normal dentate gyrus (DG) via Y1 receptors (Howell, O.W., Scharfman, H.E., Herzog, H., Sundstrom, L.E., Beck-Sickinger, A. and Gray, W.P. (2003) Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J Neurochem, 86, 646–659; Howell, O.W., Doyle, K., Goodman, J.H., Scharfman, H.E., Herzog, H., Pringle, A., Beck-Sickinger, A.G. and Gray, W.P. (2005) Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. J Neurochem, 93, 560–570). This regulation may be relevant to epilepsy, because seizures increase both NPY expression and precursor cell proliferation in the DG. Therefore, the effects of NPY on DG precursors were evaluated in normal conditions and after status epilepticus. In addition, potentially distinct NPY-responsive precursors were identified, and an analysis performed not only of the DG, but also the caudal subventricular zone (cSVZ) and subcallosal zone (SCZ) where seizures modulate glial precursors. We show a proliferative effect of NPY on multipotent nestin cells expressing the stem cell marker Lewis-X from both the DG and the cSVZ/SCZ in vitro. We confirm an effect on proliferation in the cSVZ/SCZ of Y1 receptor−/− mice and demonstrate a significant reduction in basal and seizure-induced proliferation in the DG of NPY−/− mice.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: NPY; Neurogenesis; Progenitor cell; Stem cell; Epilepsy; Cell culture; Nestin; Subventricular zone; Subcallosal zone; Dentate gyrus
Additional Information: Corrigendum to “Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus” [Neurobiol. Dis. 26/1 (2007) 174–188] published in Neurobiology of Disease, Volume 49, January 2013, Page 199, http://dx.doi.org/10.1016/j.nbd.2012.06.006
Publisher: Elsevier
ISSN: 0969-9961
Last Modified: 04 Jun 2017 06:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/57113

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