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Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling

Budreck, E. C., Kwon, O.-B., Jung, J. H., Baudouin, Stephane J., Thommen, A., Kim, H.-S., Fukazawa, Y., Harada, H., Tabuchi, K., Shigemoto, R., Scheiffele, P. and Kim, J.-H. 2013. Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling. Proceedings of the National Academy of Sciences of the United States of America 110 (2) , pp. 725-730. 10.1073/pnas.1214718110

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Abstract

Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1 subunit. Our work uncovers NL1 isoform-specific cis-interactions with ionotropic glutamate receptors as a key mechanism for controlling synaptic properties.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: synapse; neurotranmitter receptor; neurexin
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 04 Jun 2017 06:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/57107

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