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Small molecule inhibitors of West Nile virus

Elseginy, Samia Ali, Massarotti, Alberto, Nawwar, Galal A. M., Amin, Kamilia M. and Brancale, Andrea 2014. Small molecule inhibitors of West Nile virus. Antiviral Chemistry & Chemotherapy 23 , pp. 179-187. 10.3851/IMP2581

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Abstract

West Nile virus is a human pathogen which is rapidly expanding worldwide. It is a member of the Flavivirus genus and it is transmitted by mosquitos between its avian hosts and occasionally in vertebrate hosts. In humans, the infection is often asymptomatic, but the most severe cases result in encephalitis or meningitis. Around 10% of cases of neuroinvasive disease are fatal. To date there is no effective human vaccine or effective antiviral therapy available to treat WNV infections For this reason, research in this field is rapidly growing. In this article we will review the latest efforts in the design and development of novel WNV inhibitors from a medicinal chemistry point of view, highlighting challenges and opportunities for the researchers working in this field.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Publisher: International Medical Press
ISSN: 0956-3202
Date of First Compliant Deposit: 30 March 2016
Last Modified: 29 Jun 2019 15:56
URI: http://orca-mwe.cf.ac.uk/id/eprint/56809

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