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Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan

Simpson, Russell Michael 2010. Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan. PhD Thesis, Cardiff University.

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Abstract

Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation. This mechanism may have direct implications for modifying the wound healing response, particularly for developing therapeutic strategies to improve healing in the elderly

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Date of First Compliant Deposit: 30 March 2016
Last Modified: 19 Mar 2016 23:32
URI: http://orca-mwe.cf.ac.uk/id/eprint/55467

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