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Design and synthesis of new potential drugs for the treatment of human African trypanosomiasis

Baliani, Alessandro 2005. Design and synthesis of new potential drugs for the treatment of human African trypanosomiasis. PhD Thesis, Cardiff University.

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Abstract

All the compounds were assayed for their ability to inhibit adenosine uptake by the P2 transporter. In vitro toxicity against intact bloodstream form trypomastigotes of T. b. brucei and T. b. rhodesiense was also measured. Compound 6 and compound 54 showed IC 50 against T. b. rhodesience line of 25 nM and 18 nM respectively. Two compounds retained their trypanocidal effect in mice curing all the mice infected with a STIB 795 T. b. brucei model of infection. One compound cured also 1 mouse of 4 infected with the more stringent model STIB 900 T. b. rhodesiense . The comet assay showed that the compound is not genotoxic at the doses tested, indicating that this is a good drug lead against HAT

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Date of First Compliant Deposit: 30 March 2016
Last Modified: 09 Jan 2018 20:24
URI: http://orca-mwe.cf.ac.uk/id/eprint/55417

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