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The design, synthesis and evaluation of some novel antiviral nucleosides

Angell, Annette 2005. The design, synthesis and evaluation of some novel antiviral nucleosides. PhD Thesis, Cardiff University.

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Abstract

An investigation into the pH stability of the BCNAs was also carried out and the parent analogue bearing a pentyphenyl side chain was found to be stable at a range of pHs. Finally, with the X-ray crystal structure of VZV thymidine kinase published we began a preliminary investigation into the possible interaction the BCNAs with this enzyme using molecular modelling

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Date of First Compliant Deposit: 30 March 2016
Last Modified: 09 Jan 2018 19:31
URI: http://orca-mwe.cf.ac.uk/id/eprint/55384

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