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The role of schizophrenia susceptibility genes in hippocampal-dependent long-term memory in the adult rat

Kirtley, Anne Elizabeth Georgina. 2010. The role of schizophrenia susceptibility genes in hippocampal-dependent long-term memory in the adult rat. PhD Thesis, Cardiff University.

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Abstract

This thesis investigates whether genes that have been associated with schizophrenia have a role in hippocampal-dependent long-term memory. Schizophrenia is psychiatric disorder in which individuals experience, amongst other symptoms, cognitive difficulties including long­ term memory (LTM) impairments. The functional roles of many schizophrenia susceptibility genes remain unknown. In this study, a selection of schizophrenia susceptibility genes and their splice variants, in particular Neuregulin 1 (Nrg1), Dysbindin 1 (Dtnbpl), Disrupted-in- schizophrenia 1 (Disci) and Early growth response factor 3 (Egr3), were hypothesized to be regulated in association with the processes of LTM. The contextual fear conditioning behavioural paradigm in which a rat associates an electric footshock with a distinct context was used to investigate hippocampal-dependent LTM.

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Funders: Medical Research Council
Date of First Compliant Deposit: 30 March 2016
Last Modified: 19 Mar 2016 23:29
URI: http://orca-mwe.cf.ac.uk/id/eprint/54151

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