Smart screens for thyroid disrupting substances in the environment

Thomas, Gethin Owain 2006. Smart screens for thyroid disrupting substances in the environment. PhD Thesis, Cardiff University.

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Abstract

The interaction of recombinant TR with TRE-containing double-stranded DNA duplexes was monitored using the electrophoretic shift assay (EMSA). A protein titration allowed the calculation of the K& of TR for DNA. This quantitation of the affinity of TR for DNA was subsequently measured in the presence of known T3 analogues, thus providing the basis of a TR-DNA binding assay.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Funders:	Biotechnology and Biological Sciences Research Council (BBSRC), MLT Research Ltd
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 Feb 2016 23:11
URI:	https://orca.cardiff.ac.uk/id/eprint/54105

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