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Gene expression and genetic diversity of the 'Streptococcus milleri' group.

Brown, Jonathon David. 2004. Gene expression and genetic diversity of the 'Streptococcus milleri' group. PhD Thesis, Cardiff University.

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Abstract

A protocol for the analysis of preferential gene expression was devised and validated. Analysis revealed possible sequence upregulation of RNA polymerase beta subunits, pyruvate formate lyase activating enzyme and a deoxyglucose epimerase enzyme at pH 7.0. The colonisation patterns in all sites were shown to be complex with many different clonotypes of a given species present. Interestingly, over time the colonisation patterns were not stable with significant changes in the species representation. The <italic>Streptococcus anginosus</italic> group has been show to display a significant amount of genomic diversity during <italic> in-vitro</italic> culture.

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Chemistry
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Date of First Compliant Deposit: 30 March 2016
Last Modified: 09 Jan 2018 22:05
URI: http://orca-mwe.cf.ac.uk/id/eprint/54077

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