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Nitric oxide in acute rejection in renal tran

Khanafer, Adib 2013. Nitric oxide in acute rejection in renal tran. MPhil Thesis, Cardiff University.
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Relul tansplantation is the teatrrent of choice for ESRF. The gpaft survival is deterrdned by several factors. One of tlre most important faclors is acute rejwtion (AR), whic,h commonly occunl in the first 3 montbs following renral tansplantation Ttre incidemce of AR is l540%o, but this depends on the irnnunosuppressive regime used. The erly diagnosis md treatuent of AR is mandatory to prev€ff long-term sequelae of AR The gold stmdard test to diagnose AR is renal biopsy which is invasive, orpmsive, require ocperiemcd pe,rsorme! with results reportd aften 6-8 hours. Nitic oxide (NO) is one rmique molecule with a proven role in AR However, our interct in NO is whether it rises significmtly enrough in the peripheral blood tbal it cm be measurd ard aid in the diaenosis of AR We aim to find out vfuether NO can be used as ar alternative non-invasive test or mrken to diagnose AR We also measurd NO with other post renal transplatr complications (PRTC) GnI, tactolimus toxicity tTIl md peritoneal dialysis poitonitis [PDPD which may mimic AR

Item Type: Thesis (MPhil)
Status: Unpublished
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Date of First Compliant Deposit: 30 March 2016
Last Modified: 19 Mar 2016 23:28

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