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Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism

Baudouin, Stephane J., Gaudias, Julien, Gerharz, Stefan, Hatstatt, Laetitia, Zhou, Kuikui, Punnakkal, Pradeep, Tanaka, Kenji F., Spooren, Will, Hen, Rene, De Zeeuw, Chris I., Vogt, Kaspar and Scheiffele, Peter 2012. Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism. Science 338 (6103) , pp. 128-132. 10.1126/science.1224159

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Abstract

The genetic heterogeneity of autism poses a major challenge for identifying mechanism-based treatments. A number of rare mutations are associated with autism, and it is unclear whether these result in common neuronal alterations. Monogenic syndromes, such as fragile X, include autism as one of their multifaceted symptoms and have revealed specific defects in synaptic plasticity. We discovered an unexpected convergence of synaptic pathophysiology in a nonsyndromic form of autism with those in fragile X syndrome. Neuroligin-3 knockout mice (a model for nonsyndromic autism) exhibited disrupted heterosynaptic competition and perturbed metabotropic glutamate receptor–dependent synaptic plasticity, a hallmark of fragile X. These phenotypes could be rescued by reexpression of neuroligin-3 in juvenile mice, highlighting the possibility of reverting neuronal circuit alterations in autism after the completion of development.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Last Modified: 04 Jun 2017 05:33
URI: http://orca-mwe.cf.ac.uk/id/eprint/51916

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