The role of GluA1 in ocular dominance plasticity in the mouse visual cortex

Ranson, Adam ORCID: https://orcid.org/0000-0002-4804-0832, Sengpiel, Frank ORCID: https://orcid.org/0000-0002-7060-1851 and Fox, Kevin Dyson ORCID: https://orcid.org/0000-0002-2563-112X 2013. The role of GluA1 in ocular dominance plasticity in the mouse visual cortex. Journal of Neuroscience 33 (38) , pp. 15220-15225. 10.1523/JNEUROSCI.2078-13.2013

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Abstract

Ocular dominance plasticity is a widely studied model of experience-dependent cortical plasticity. It has been shown that potentiation of open eye responses resulting from monocular deprivation relies on a homeostatic response to loss of input from the closed eye, but the mechanisms by which this occurs are not fully understood. The role of GluA1 in the homeostatic component of ocular dominance (OD) plasticity has not so far been tested. In this study, we tested the idea that the GluA1 subunit of the AMPA receptor is necessary for open eye potentiation. We found that open eye potentiation did not occur in GluA1 knock-out (GluA1−/−) mice but did occur in wild-type littermates when monocular deprivation was imposed during the critical period. We also found that depression of the closed eye response that normally occurs in the monocular as well as binocular zone is delayed, but only in the monocular zone in GluA1−/− mice and only in a background strain we have previously shown lacks synaptic scaling (C57BL/6OlaHsd). In adult mice, we found that OD plasticity and facilitation of OD plasticity by prior monocular experience were both present in GluA1−/− mice, suggesting that the GluA1-dependent mechanisms only operate during the critical period.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH301 Biology
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Funders:	BBSRC, MRC, EU FP7
Date of First Compliant Deposit:	30 March 2016
Last Modified:	10 Feb 2024 02:18
URI:	https://orca.cardiff.ac.uk/id/eprint/51422

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