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Concise review: Immune recognition of induced pluripotent stem cells

Boyd, Ashleigh S., Rodrigues, Neil, Lui, Kathy O., Fu, Xuemei and Xu, Yang 2012. Concise review: Immune recognition of induced pluripotent stem cells. Stem Cells 30 (5) , pp. 797-803. 10.1002/stem.1066

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Abstract

Autologous-induced pluripotent stem cells (iPSCs) may eventually be used in cell replacement therapies to treat a wide range of diseases and have been touted as a solution to the vexing problem of immune rejection in this context. Emerging evidence suggests, however, that ostensibly histocompatible iPSCs may be rejected following transplantation. Here, we review the mechanisms that contribute to immunogenicity in iPSCs and forward approaches to permit their acceptance in potential cell replacement therapies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords: Stem cells; Embryonic stem cells; Induced pluripotent stem cells; Cell replacement therapy; Immunogenicity; Transplantation; Tolerance; Rejection; Regenerative medicine
Publisher: AlphaMed Press
ISSN: 1066-5099
Last Modified: 04 Jun 2017 05:21
URI: http://orca-mwe.cf.ac.uk/id/eprint/51133

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