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Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity

Chakraborty, Mallinath, McGreal, Eamon Patrick, Davies, Philip Lloyd, Nowell, Mari Ann, Jones, Simon Arnett and Kotecha, Sailesh 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104 (3) , pp. 161-167. 10.1159/000351015

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Abstract

Background: Interleukin-6 (IL-6) signalling involves the interplay between IL-6, soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130). IL-6 activity is modulated by the soluble receptors to produce both pro- and anti-inflammatory effects in human diseases and animal models. The expression and functional activity of these molecules in lungs of preterm ventilated infants is unknown. Objectives: We investigated this pathway in preterm infants who were at risk of developing chronic lung disease of prematurity (CLD). Methods: Cytokines and soluble receptors were measured in bronchoalveolar lavage fluid (BALF) from ventilated preterm infants ≤32 weeks of gestation who did or did not develop CLD. B9 cells, which specifically proliferate to IL-6, were used to assess BALF IL-6 functional activity. Results: Inflammatory cells, IL-8 and monocyte chemotactic protein-1 were increased in BALF from the CLD group when compared to the No CLD group (p < 0.05). BALF IL-6 and sIL-6R were similar in both groups. In contrast, BALF sgp130 and sgp130/sIL-6R were greater in the CLD group when compared to the No CLD group (p = 0.01 and p = 0.02, respectively). However, the increased BALF sgp130 did not appear to modulate the BALF IL-6 functional activity. Conclusion: Lung inflammation was observed in the CLD group. Increased BALF sgp130 was noted in the CLD group but it did not appear to modulate the pulmonary IL-6 bioactivity. Further research is needed to investigate the potential modulatory activity of sgp130 in the preterm lung.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
Publisher: Karger
ISSN: 1661-7819
Last Modified: 14 Sep 2018 21:34
URI: http://orca-mwe.cf.ac.uk/id/eprint/50495

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