A comparative study of conventional and controlled-release formulations of trazodone in elderly depressed patients

Bayer, Antony James ORCID: https://orcid.org/0000-0002-7514-248X, Pathy, M. S. J., Cameron, A., Venkateswalu, T., Ather, S. A., Mankikar, G. D. and Ghosh, A. K. 1989. A comparative study of conventional and controlled-release formulations of trazodone in elderly depressed patients. Clinical Neuropharmacology 12 (Supp 1) , s50-s55.

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Abstract

One hundred sixty-six elderly depressed patients were recruited from six hospital centers and entered in a double-blind, randomized, parallel group comparative study of conventional and controlled-release formulations of trazodone. Patients received a single nighttime dose of 100 mg for 1 week, followed by 3 weeks of 200 mg or less, depending upon tolerance. Efficacy was measured using the modified Hamilton depression rating scale and global assessments of the severity of depression and improvement relative to baseline. Both treatments were equally effective with 39 (68%) patients completing 4 weeks of treatment with the conventional formulation and 41 (77%) patients completing 4 weeks treatment with the controlled-release formulation rated as very much improved. Sleep improved shortly after initiation of treatment in most patients and there were no significant differences between groups. There was a tendency for fewer side effects to be recorded during the first week of treatment in patients receiving the controlled-release formulation but no difference reached statistical significance.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0362-5664
Related URLs:	Publisher
Last Modified:	24 Oct 2022 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/50066

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