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The extracellular calcium-sensing receptor, CaSR, in fetal development

Riccardi, Daniela, Brennan, Sarah C. and Chang, Wenhan 2013. The extracellular calcium-sensing receptor, CaSR, in fetal development. Best Practice & Research Clinical Endocrinology & Metabolism 27 (3) , pp. 443-453. 10.1016/j.beem.2013.02.010

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In fetal mammals, serum levels of both total and ionized calcium significantly exceed those in the adult. This relative fetal hypercalcemia is crucial for skeletal development and is maintained irrespectively of maternal serum calcium levels. Elegant studies by Kovacs and Kronenberg have previously addressed the role of the CaSR in creating and maintaining this relative fetal hypercalcemia, through the regulation of parathyroid hormone-related peptide secretion. More recently we have shown that the CaSR is widely distributed throughout the developing fetus, where the receptor plays major, unexpected roles in ensuring growth and maturation of several organs. In this article, we present evidence for a role of the CaSR in the control of skeletal development, and how fetal hypercalcemia, acting through the CaSR, regulates lung development.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QP Physiology
Publisher: Elsevier
ISSN: 1521-690X
Funders: Marie Curie ITN, BBSRC
Date of First Compliant Deposit: 30 March 2016
Last Modified: 07 Jul 2017 18:45

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