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A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment

Burnett, Alan Kenneth, Milligan, Donald, Prentice, Archie G., Goldstone, Anthony H., McMullin, Mary F., Hills, Robert Kerrin and Wheatley, Keith 2007. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer 109 (6) , pp. 1114-1124. 10.1002/cncr.22496

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Abstract

n this study, patients with acute myeloid leukemia or high-risk myelodysplastic syndrome who were unfit for intensive chemotherapy were randomized to receive either low-dose cytarabine (ara-C) or hydroxyurea with or without all-trans retinoic acid. The results indicted that low-dose ara-C was superior to best supportive care and hydroxyurea and may represent standard care against which new treatments are compared in this patient group.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Wiley-Blackwell
ISSN: 0008-543X
Last Modified: 25 Jun 2017 04:19
URI: http://orca-mwe.cf.ac.uk/id/eprint/49736

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