Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Linkage disequilibrium and historical effective population size in the Thoroughbred horse

Corbin, Laura J., Blott, S. C., Swinburne, J. E., Vaudin, M., Bishop, S. C. and Woolliams, J. A. 2010. Linkage disequilibrium and historical effective population size in the Thoroughbred horse. Animal Genetics 41 (S2) , pp. 8-15. 10.1111/j.1365-2052.2010.02092.x

Full text not available from this repository.

Abstract

Many genomic methodologies rely on the presence and extent of linkage disequilibrium (LD) between markers and genetic variants underlying traits of interest, but the extent of LD in the horse has yet to be comprehensively characterized. In this study, we evaluate the extent and decay of LD in a sample of 817 Thoroughbreds. Horses were genotyped for over 50,000 single nucleotide polymorphism (SNP) markers across the genome, with 34,848 autosomal SNPs used in the final analysis. Linkage disequilibrium, as measured by the squared correlation coefficient (r(2)), was found to be relatively high between closely linked markers (>0.6 at 5 kb) and to extend over long distances, with average r(2) maintained above non-syntenic levels for single nucleotide polymorphisms (SNPs) up to 20 Mb apart. Using formulae which relate expected LD to effective population size (N(e)), and assuming a constant actual population size, N(e) was estimated to be 100 in our population. Values of historical N(e), calculated assuming linear population growth, suggested a decrease in N(e) since the distant past, reaching a minimum twenty generations ago, followed by a subsequent increase until the present time. The qualitative trends observed in N(e) can be rationalized by current knowledge of the history of the Thoroughbred breed, and inbreeding statistics obtained from published pedigree analyses are in agreement with observed values of N(e). Given the high LD observed and the small estimated N(e), genomic methodologies such as genomic selection could feasibly be applied to this population using the existing SNP marker set.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Business (Including Economics)
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QL Zoology
Uncontrolled Keywords: effective population size; horse; linkage disequilibrium; population history; single nucleotide polymorphism; Thoroughbred
Publisher: Wiley-Blackwell
ISSN: 1365-2052
Last Modified: 19 Mar 2016 23:22
URI: http://orca-mwe.cf.ac.uk/id/eprint/48883

Citation Data

Cited 32 times in Google Scholar. View in Google Scholar

Cited 68 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item