An international field study of the EORTC QLQ-PR25: a questionnaire for assessing the health-related quality of life of patients with prostate cancer

van Andel, George, Bottomley, Andrew, Fosså, Sophie D., Efficace, Fabio, Coens, Corneel, Guerif, Stephane, Kynaston, Howard, Gontero, Paolo, Thalmann, George, Akdas, Atif, D?Haese, Sven and Aaronson, Neil K. 2008. An international field study of the EORTC QLQ-PR25: a questionnaire for assessing the health-related quality of life of patients with prostate cancer. European Journal of Cancer 44 (16) , pp. 2418-2424. 10.1016/j.ejca.2008.07.030

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Abstract

Aim: To evaluate the psychometrics of the EORTC QLQ-PR25, a questionnaire assessing the health-related quality of life of prostate cancer patients. Methods: The QLQ-PR25 and the QLQ-C30 were administered to 642 prostate cancer patients from 13 countries treated with curative or palliative intent. The QLQ-PR25 assesses urinary, bowel and sexual symptoms and functioning, and the side-effects of hormonal treatment. Results: Five hundred and nine patients were available for the final analysis. Multitrait scaling analyses confirmed the hypothesised scale structure of the QLQ-PR25. Internal consistency reliability was good (coefficient α = 0.70–0.86) for the urinary symptoms and sexual function scales, but lower for the bowel function and side-effects of hormonal treatment scales (α < 0.70). The module discriminated clearly between clinically distinct patient subgroups, and was responsive to changes in health status over time. Conclusion: In general, the QLQ-PR25 demonstrates acceptable psychometric properties and clinical validity. Some caution should be used in interpreting the bowel function and side-effects of hormonal therapy scales; results can be reported at the individual item and scale level.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Prostate cancer; Quality of life; Patient-reported outcome; Questionnaire; Bladder function; Urinary function; Sexuality
Publisher:	Elsevier
ISSN:	0959-8049
Last Modified:	04 Jun 2017 05:06
URI:	http://orca-mwe.cf.ac.uk/id/eprint/48543

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