Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia

Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958, Stergiakouli, Evangelia, Langley, Kate ORCID: https://orcid.org/0000-0002-2033-2657, Martin, Joanna ORCID: https://orcid.org/0000-0002-8911-3479, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Kent, L., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Gill, M., Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203 (2) , pp. 107-111. 10.1192/bjp.bp.112.117432

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Abstract

Background: There is recent evidence of some degree of shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants. Aims: To determine whether there is overlap between common alleles conferring risk of schizophrenia in adults with those that do so for ADHD in children. Method: We used recently published Psychiatric Genome-wide Association Study (GWAS) Consortium (PGC) adult schizophrenia data to define alleles over-represented in people with schizophrenia and tested whether those alleles were more common in 727 children with ADHD than in 2067 controls. Results: Schizophrenia risk alleles discriminated ADHD cases from controls (P = 1.04 × 10–4, R2 = 0.45%); stronger discrimination was given by alleles that were risk alleles for both adult schizophrenia and adult bipolar disorder (also derived from a PGC data-set) (P = 9.98 × 10–6, R2 = 0.59%). Conclusions: This increasing evidence for a small, but significant, shared genetic susceptibility between adult schizophrenia and childhood ADHD highlights the importance of research work across traditional diagnostic boundaries.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Systems Immunity Research Institute (SIURI) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Funders:	Wellcome Trust, Medical Research Council, NIHR
Date of First Compliant Deposit:	30 March 2016
Last Modified:	02 Oct 2023 17:29
URI:	https://orca.cardiff.ac.uk/id/eprint/48093

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