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Effect of Gender and Device Mouthpiece Shape on Bolus Insulin Aerosol Delivery Using the AERxPulmonary Delivery System

Boyd, Brooks, Noymer, Peter, Liu, Kui, Okikawa, Jerry, Hasegawa, Dave, Warren, Simon, Taylor, Glyn, Ferguson, Elizabeth, Schuster, Jeff, Farr, Stephen and Gonda, Igor 2004. Effect of Gender and Device Mouthpiece Shape on Bolus Insulin Aerosol Delivery Using the AERxPulmonary Delivery System. Pharmaceutical Research 21 (10) , pp. 1776-1782. 10.1023/B:PHAM.0000045228.32419.ba

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Abstract

Purpose. A study was designed to compare differences in insulin aerosol deposition profiles in healthy male and female subjects, as well as examine the effect of mouthpiece cross-sectional shape, volume, and taper on deposition profiles using a developmental AERx pulmonary delivery system. Methods. >Six mouthpieces were screened in the laboratory, and three were selected for clinical investigation: a cylindrical mouthpiece with constant-cross-sectional area, an elliptical mouthpiece with constant-cross-sectional area, and a tapered elliptical mouthpiece with an exit cross-sectional area equal to one half the entrance cross-sectional area. Results. There was no significant difference in the lung dose or in the deposition pattern between males and females (p > 0.05, by ANOVA). The cross-sectional shape of the mouthpiece had no significant effect on the clinical lung dose or the deposition pattern (p > 0.05, by ANOVA), although in vitrotesting showed lower emitted dose values with the tapered elliptical mouthpiece (by ANOVA and Duncan's multiple range test, α = 0.05). Using the tapered mouthpiece in the clinic resulted in significantly more deposition on the mouthpiece itself when compared to the nontapered mouthpieces. Conclusion. Inhalation of insulin using the AERx system was insensitive to differences in male and female respiratory tract geometry across all mouthpiece designs examined.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: AERx; gender differences; mouthpiece design; pulmonary drug delivery; scintigraphy
Publisher: Springer
ISSN: 0724-8741
Last Modified: 04 Jun 2017 04:55
URI: http://orca-mwe.cf.ac.uk/id/eprint/46440

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