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A comparison of carbohydrate deficient transferrin with other markers of alcohol misuse in male soldiers under the age of thirty

Bisson, Jonathan Ian and Milford-Ward, A. 1994. A comparison of carbohydrate deficient transferrin with other markers of alcohol misuse in male soldiers under the age of thirty. Alcohol and Alcoholism 29 (3) , pp. 315-321.

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Abstract

The paper describes a study of 58 consecutive male soldiers under 30 years old admitted to an alcohol treatment unit in London, and 51 age- and gender-matched controls to compare the efficacy of isoelectric focusing, a non-quantitative measure of carbohydrate deficient transferrin (CDT), with other markers of alcohol misuse. The Severity of Alcohol Dependence Questionnaire, the Michigan Alcohol Screening Test and the CAGE questions were all more sensitive in detecting alcohol misusers than the laboratory markers measured. At standard cut-off levels, the laboratory markers yielded low sensitivities even in those subjects who admitted to drinking over 80 g alcohol daily for at least 3 weeks immediately prior to the study. CDT was the most sensitive (31%), followed by mean cell volume (14%) and gamma glutamyl transferase (11%). The questionnaires and laboratory markers had good specificities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: H Social Sciences > HV Social pathology. Social and public welfare
R Medicine > R Medicine (General)
Publisher: Oxford University Press
ISSN: 0735-0414
Related URLs:
Last Modified: 04 Jun 2017 04:52
URI: http://orca-mwe.cf.ac.uk/id/eprint/45848

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