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Imaging pain in arthritis: Advances in structural and functional neuroimaging

Harvey, Ann, Taylor, Ann Margaret and Wise, Richard Geoffrey 2012. Imaging pain in arthritis: Advances in structural and functional neuroimaging. Current Pain and Headache Reports 16 (6) , pp. 492-501. 10.1007/s11916-012-0297-4

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Abstract

Arthritis is a heterogeneous disease characterized by joint stiffness, swelling, and pain. Although primarily considered a peripheral joint disease, the severity of pain reported by arthritis patients does not always reflect the extent of joint pathology detectable by conventional means. Using structural and functional brain imaging techniques, a growing number of evolving neuroimaging methods are providing insight into these observed discrepancies at different time-scales. Of these methods, functional magnetic resonance imaging is exploited for short-term evoked pain examination and treatment evaluation; 'resting-state' approaches provide insight into fluctuations in pain; perfusion imaging captures elements of on-going clinical pain; and morphological brain assessment provides evidence for long-term structural changes in the brain associated with chronic pain. Further insight into arthritic pain processing at the brain-systems level could in the future be provided by combined neuroimaging approaches, specifically investigating the interactions between functional and structural alterations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Springer
ISSN: 1531-3433
Last Modified: 04 Jun 2017 04:47
URI: http://orca-mwe.cf.ac.uk/id/eprint/44715

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