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Current trends in biomaterial coatings

Mikhalovsky, S. V., Santin, M., Mikhalovska, L. I., Lloyd, A. W. and Denyer, Stephen Paul 2003. Current trends in biomaterial coatings. Nanostructured Materials and Coatings for Biomedical and Sensor Applications 102 , pp. 15-26. 10.1007/978-94-010-0157-1_2

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Abstract

Our understanding and use of biomaterials evolves according to our understanding of the phenomenon of biocompatibility. in earlier days, biocompatibility was synonymous with the word ‘inertness’. Attempts to create such an inert biomaterial, however, failed. As a result, the quest for a perfect biomaterial has shifted from seeking an inert one to a material that interacts with the biosystem it is in contact with in the same way as a natural material would react in the same place. Respectively, biocompatibility is defined as “the ability of a material, device or system to perform without a clinically significant host response in a specific application” [1]. Although bulk properties of biomaterials, such as mechanical strength and optical properties, are equally important for their performance, surface properties are most closely related to their biocompatibility. Complexity of interfacial phenomena at the ‘biomaterial — biological medium’ interface is hard to overestimate. They include adsorption (of water, proteins, low molecular solutes, etc.), ion exchange, cell and bacterial adhesion, corrosion and decomposition of biomaterial, catalytic effects and so on. Adsorbed proteins can change their conformation and trigger cascades of events in the body, such as complement activation, blood clotting, release of inflammatory cytokines and other effects comprising response of the organism to the foreign material and, in general, to the damage caused by its implantation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Springer Verlag
Last Modified: 19 Mar 2016 23:14
URI: https://orca.cardiff.ac.uk/id/eprint/44300

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