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A standard strain of human ocular keratocytes

Dropcova, S., Denyer, Stephen Paul, Lloyd, A. W., Gard, P. R., Hanlon, G. W., Mikhalovsky, S. V., Sandeman, S., Olliff, C. J. and Faragher, R. G. A. 1999. A standard strain of human ocular keratocytes. Ophthalmic Research 31 (1) , pp. 33-41. 10.1159/000055510

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The ability of an injured cornea to regenerate from deep tissue trauma is largely due to wound healing processes mediated by the surviving stromal keratocytes. Despite the importance of the wound healing process, and the ease with which keratocytes can be grown in tissue culture, a standardised strain of the cells has never been made available. Accordingly, this study reports a strain of human embryonic keratocytes, designated EK1.BR as a research tool for the ophthalmic community. EK1.BR has been characterised with respect to life-span, fraction of dividing cells and maintenance of a keratocyte phenotype in culture. It is hoped that these cells will prove useful in the in vitro study of stromal wound healing and the characterisation of keratocyte gene expression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RE Ophthalmology
R Medicine > RM Therapeutics. Pharmacology
Publisher: Karger
ISSN: 0030-3747
Last Modified: 19 Mar 2016 23:14

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