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Glycocalyx adsorption enhances biocompatibility of poly(methyl methacrylate)

Faragher, R. G. A., Nagri, S., Dropcova, S., Mikhalovsky, S. V., Lloyd, A. W., Hanlon, G. W., Olliff, C. J., Gard, P. R. and Denyer, Stephen Paul 1996. Glycocalyx adsorption enhances biocompatibility of poly(methyl methacrylate). Presented at: FOA 5: Fifth International Conference on Fundamentals of Adsorption, Pacific Grove, CA, USA, 13-18 May 1995. Published in: LeVan, M. D. ed. Fundamentals of Adsorption: Proceedings of the Fifth International Conference on Fundamentals of Adsorption. The Kluwer International Series in Engineering and Computer Science , vol. 356. Boston, MA: Springer, pp. 285-292. 10.1007/978-1-4613-1375-5_34

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Abstract

A major goal of modern biocompatibility is to identify factors which will inhibit the attachment of various cell types to implanted prosthetic devices. The glycocalyx of mammalian cells is a loosely defined network of lipids, proteoglycans and proteins which forms the outer layer of mammalian cells. Components of the glycocalyx are known to mediate cell adhesion and are an obvious area of interest in the development of biocompatible coatings. This report describes the development of an assay system capable of evaluating the effects of single glycocalyx components on mammalian cell attachment and the correlation of those effects with the changes observed in the dynamic contact angles of the test surfaces. The data suggest that physical-chemical and biological tests have the potential to be used in tandem in the development of more biocompatible implants.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Springer
ISBN: 9781461285946
Last Modified: 19 Mar 2016 23:14
URI: http://orca-mwe.cf.ac.uk/id/eprint/44275

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