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Control of staphylococcal adhesion to polystyrene surfaces by polymer surface modification with surfactants

Bridgett, M. J., Davies, M. C. and Denyer, Stephen Paul 1992. Control of staphylococcal adhesion to polystyrene surfaces by polymer surface modification with surfactants. Biomaterials 13 (7) , pp. 411-416. 10.1016/0142-9612(92)90159-L

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Abstract

The adherence of three clinical isolates of Staphylococcus epidermidis to model polystyrene surfaces was studied in vitro using epifluorescent image analysis. A series of 16 Pluronic surfactants (A-B-A block copolymers where A is poly(ethylene oxide) (PEO) and B is poly(propylene oxide) (PPO)) were used as surface modifiers for the model polystyrene surfaces. Substantial reductions (up to 97%) in bacterial adhesion levels were achieved with all copolymers tested, irrespective of the PPO or PEO block lengths. It appears likely that such treatments create a sterically stabilized surface with adsorbed PEO chains, conferring non-specific anti-adhesive properties which can limit bacterial attachment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Bacterial adhesion; surfactants; surface modification
Publisher: Elsevier
ISSN: 0142-9612
Last Modified: 19 Mar 2016 23:14
URI: http://orca-mwe.cf.ac.uk/id/eprint/44250

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