Toxicity of amphotericin B emulsion to cultured canine kidney cell monolayers

Lamb, K. A., Washington, C., Davis, S. S. and Denyer, Stephen Paul 1991. Toxicity of amphotericin B emulsion to cultured canine kidney cell monolayers. Journal of Pharmacy and Pharmacology 43 (7) , pp. 522-524. 10.1111/j.2042-7158.1991.tb03529.x

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Abstract

The effect of amphotericin B in an emulsion formulation on the integrity of monolayers of kidney cells has been studied. Whereas a conventional solubilized amphotericin formulation (Fungizone, Squibb) caused a loss in monolayer integrity at concentrations above 1 μg mL−1, the emulsion formulation had no measurable effect on confluence at amphotericin concentrations up to 100 μg mL−1. The emulsion retained a comparable antifungal activity to that of Fungizone against Saccharomyces cerevisiae in suspension culture. These results parallel the observed erythrocyte lysis data obtained previously using amphotericin B emulsions, and suggest that the emulsion formulation may have a lower toxicity and improved therapeutic potential over existing formulations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology
Publisher:	Wiley-Blackwell
ISSN:	2042-7158
Last Modified:	19 Mar 2016 23:14
URI:	https://orca.cardiff.ac.uk/id/eprint/44244

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