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The biochemical basis of synergy between the antibacterial agents, chlorocresol and 2-phenylethanol

Denyer, Stephen Paul, Hugo, W. B. and Harding, V. D. 1986. The biochemical basis of synergy between the antibacterial agents, chlorocresol and 2-phenylethanol. International Journal of Pharmaceutics 29 (1) , pp. 29-36. 10.1016/0378-5173(86)90196-1

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Abstract

The combined antimicrobial action of chlorocresol and 2-phenylethanol has been investigated. Synergy in growth inhibition experiments was reflected by increased membrane permeability to hydrogen, potassium and phosphate ions and an inability to accumulate glutamate actively. No gross disruptive effects on the membrane were observed. ATP synthesis and glucose uptake were largely unaffected by combinations of these two agents despite a marked inhibition of respiratory activity. The biochemical basis of synergy is believed to result from a combined action on the generation and coupling of a proton gradient to active solute transport and retention processes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: chlorocresol; 2-phenylethanol; preservatives; preservative combinations; biochemical basis of synergy; antimicrobial agents
Publisher: Elsevier
ISSN: 0378-5173
Last Modified: 19 Mar 2016 23:14
URI: http://orca-mwe.cf.ac.uk/id/eprint/44227

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