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The mode of action of l,2-benzisothiazolin-3-one on Staphylococcus aureus

Fuller, S. J., Denyer, Stephen Paul, Hugo, W. B., Pemberton, D., Woodcock, P. M. and Buckley, A. J. 1985. The mode of action of l,2-benzisothiazolin-3-one on Staphylococcus aureus. Letters in Applied Microbiology 1 (1) , pp. 13-15. 10.1111/j.1472-765X.1985.tb01478.x

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1,2-benzisothiazolin-3-one (BIT), at growth inhibitory concentrations, has little effect on membrane integrity but significantly inhibits the active transport and oxidation of glucose by washed Staphylococcus aureus cells. The dependancy of these metabolic processes on thiol-containing enzymes and the observed interaction of BIT with glutathione and isolated enzyme preparations suggests that cellular thiol groups are a major target for BIT.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Publisher: Wiley-Blackwell
ISSN: 1472-765X
Last Modified: 19 Mar 2016 23:14

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