Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The microbial degradation of topically applied drugs

Denyer, Stephen Paul, Guy, R. H., Hadgraft, J. and Hugo, W. B. 1985. The microbial degradation of topically applied drugs. International Journal of Pharmaceutics 26 (1-2) , pp. 89-97. 10.1016/0378-5173(85)90202-9

Full text not available from this repository.

Abstract

The surface of the skin supports a range of microorganisms capable of metabolizing some topically applied drugs. In order to ascertain the significance of this degradation we have established a mathematical model to predict the influence of this biotransformation on the plasma levels of the drug. The model is a linear kinetic representation of the process of skin absorption and the rate constants are predicted from a physicochemical consideration of the properties of the drug. The results of the simulations show that microbial degradation of the drug can be significant, particularly if the topical formulation is a thin film. If a transdermal device is used the theoretical calculations show that enzymatic degradation of the active substance is likely to be clinically less significant.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: microbial degradation of drugs; topical drugs; linear kinetic model; skin absorption; transdermal drug device
Publisher: Elsevier
ISSN: 0378-5173
Last Modified: 19 Mar 2016 23:14
URI: http://orca-mwe.cf.ac.uk/id/eprint/44225

Citation Data

Cited 43 times in Google Scholar. View in Google Scholar

Cited 18 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item