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Ageing of the retinal pigment epithelium: implications for transplantation

Boulton, Michael Edwin, Rozanowska, Malgorzata Barbara and Wess, Timothy James 2004. Ageing of the retinal pigment epithelium: implications for transplantation. Graefe's Archive for Clinical and Experimental Ophthalmology 242 (1) , pp. 76-84. 10.1007/s00417-003-0812-8

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Abstract

This review will discuss some of the implications for using cells from aged donors for retinal pigment epithelium (RPE) transplantation. It will consider age-related changes in the structure and function of RPE cells and the accumulation of potentially damaging photoreactive constituents. The review will focus on the role of the ocular pigments lipofuscin and melanin in respect to age-related changes in composition, photoreactivity and potential role in retinal ageing and age-related macular degeneration. The article concludes by considering the suitability of senescent RPE cells for transplantation and whether such cells can be rejuvenated.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Publisher: Springer
ISSN: 0721-832X
Last Modified: 13 Jan 2018 21:17
URI: http://orca-mwe.cf.ac.uk/id/eprint/44150

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