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A novel application for Cocoacrisp protein as a biomarker for experimental pulmonary fibrosis

Balharry, Dominique, Sexton, Keith, Oreffo, Victor and Berube, Kelly Ann 2009. A novel application for Cocoacrisp protein as a biomarker for experimental pulmonary fibrosis. Biomarkers 14 (6) , pp. 366-371.

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Abstract

Pulmonary fibrosis is a debilitating disease affecting up to 2 million people worldwide, with a median survival rate of only 3 years after diagnosis. The aim of this study was to evaluate a potential protein biomarker (Cocoacrisp, CC) to identify the onset of pulmonary fibrosis. A model of fibrosis was induced via intratracheal instillation of bleomycin, and samples were collected during the early phase of the disease. Immunohistochemical identification of CC was carried out in lung tissue from the bleomycin model. Quantification by image analysis showed CC levels were doubled (p <0.0003), after a single bleomycin dose, but not after double instillation. Microscopic analysis revealed that CC signal was primarily detected on the alveolar surface. The secretion of the novel protein CC during the early stages of bleomycin-induced injury may have the potential to be utilized as a clinical biomarker for the early stages of fibrosis, particularly as it may be detectable in bronchoalveolar lavage fluid.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Cocoacrisp, bleomycin, pulmonary toxicity, oedema, secreted protein
Publisher: Informa Healthcare
ISSN: 1354-750X
Last Modified: 04 Jun 2017 04:44
URI: http://orca-mwe.cf.ac.uk/id/eprint/43710

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