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Relative prognostic value of human epidermal growth factor receptor 2 (HER2) expression in operable oesophagogastric cancer

Chan, David, Campbell, Fiona, Edwards, Paul, Jasani, Bharat, Williams, Geraint Trefor and Lewis, Wyn G. 2012. Relative prognostic value of human epidermal growth factor receptor 2 (HER2) expression in operable oesophagogastric cancer. ISRN Surgery 2012 10.5402/2012/804891

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Abstract

Aims. The aim of this study was to determine the prognostic significance of HER2 receptor expression in operable oesophagogastric adenocarcinoma. Methods. Eighty-five consecutive patients diagnosed with oesophagogastric adenocarcinoma [18 oesophageal (OC), 32 junctional (JC) and 35 gastric (GC)] undergoing potentially curative resection were studied retrospectively. Immunohistochemistry was used to determine HER2 status at endoscopic biopsy and resection specimen. The primary outcome measure was survival. Results. Twenty (24%) patients had HER2 positive tumours which was commoner in JC (14/32, 44% versus 2/18, 11% in OC and 4/35, 11% in GC,

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Hindawi Publishing Group
ISSN: 2090-5793
Date of First Compliant Deposit: 30 March 2016
Last Modified: 07 Dec 2019 03:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/43644

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