Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The effects of depot long-acting somatostatin analog on central aortic pressure and arterial stiffness in acromegaly

Smith, Jamie Christina, Lane, H., Davies, N., Evans, L. M., Cockcroft, John Ronald, Scanlon, Maurice Francis and Davies, J. S. 2003. The effects of depot long-acting somatostatin analog on central aortic pressure and arterial stiffness in acromegaly. Journal of Clinical Endocrinology & Metabolism 88 (>6) , pp. 2556-61. 10.1210/jc.2002-021746

Full text not available from this repository.

Abstract

Acromegaly is associated with increased cardiovascular risk. Although conventional risk factors such as glucose intolerance, hypertension, and dyslipidemia probably contribute, there may also be direct effects of GH/IGF-I excess on the vasculature. To study the effects of GH excess on the vasculature, we have assessed arterial stiffness in acromegalic subjects with and without active disease and have investigated the effects of Sandostatin LAR (OCT-LAR) on vascular function. Sixteen normotensive subjects with acromegaly (10 males and 6 females) and 8 healthy controls were studied. Of the acromegalic subjects, eight had active disease (group A), and eight were cured (GH < 2.5 mU/liter; group B). The three groups were age, sex, and blood pressure matched. Group A subjects were restudied after 3 and 6 months of OCT-LAR therapy. Arterial stiffness was assessed by analyzing central arterial pressure waveforms derived from measured radial artery waveforms. This allowed determination of the augmentation of central pressure and the augmentation index. Lipids, glucose, and IGF-I were also measured. Comparing the three groups (ANOVA; mean

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
ISSN: 0021-972X
Last Modified: 04 Jun 2017 01:32
URI: http://orca-mwe.cf.ac.uk/id/eprint/436

Citation Data

Cited 27 times in Google Scholar. View in Google Scholar

Cited 31 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item