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Auditory threshold, phonologic demand, and incident dementia

Gallacher, John Edward, Ilubaera, Victor, Ben-Shlomo, Yoav, Bayer, Antony James, Fish, Mark, Babisch, Wolfgang and Elwood, Peter Creighton 2012. Auditory threshold, phonologic demand, and incident dementia. Neurology 79 (15) , pp. 1583-1590. 10.1212/WNL.0b013e31826e263d

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Abstract

Objective: This study was undertaken to investigate the association of auditory threshold with cognitive decline and dementia. Methods: The 1,057 surviving men of the Caerphilly cohort with audiometric data at baseline were followed for 17 years for cognitive outcomes. Pure-tone unaided audiometric threshold was assessed at 0.5, 1, 2, and 4 KHz at baseline and after 9 years. Incident dementia was assessed according to DSM-IV criteria, including standard criteria for vascular dementia and for Alzheimer disease. Cognitive decline was assessed by repeat administration of a cognitive test battery. Results: Mean age-adjusted auditory threshold across both time points was associated with incident dementia and cognitive decline. After adjustment for premorbid cognitive function, the association with dementia was retained (odds ratio0.5 KHz = 2.67; 95% confidence interval, 1.38–5.18; p = 0.004). Stronger associations with cognitive decline were found for tests administered by interview than for those administered by computer. Conclusions: This study has found an association of auditory threshold with dementia and cognitive decline over a 17-year period. The mechanisms underlying this association are unclear and may include a prodromal effect of dementia on auditory threshold, an effect of auditory threshold on cognitive assessment, an effect of auditory threshold on cognitive loss, or a shared etiologic pathway between both.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: AAN Enterprises
ISSN: 0028-3878
Last Modified: 04 Jun 2017 04:42
URI: http://orca-mwe.cf.ac.uk/id/eprint/43287

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