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Defolliculated (Dfl): a dominant mouse mutation leading to poor sebaceous gland differentiation and total elimination of pelage follicles

Porter, Rebecca ORCID: https://orcid.org/0000-0001-6748-0916, Jahoda, Colin A. B., Lunny, Declan P., Henderson, Gayle, Ross, Jane, McLean, W. H. Irwin, Whittock, Neil V., Wilson, Neil J., Reichelt, Julia, Magin, Thomas M. and Lane, E Birgitte 2002. Defolliculated (Dfl): a dominant mouse mutation leading to poor sebaceous gland differentiation and total elimination of pelage follicles. Journal of Investigative Dermatology 119 (1) , pp. 32-7. 10.1046/j.1523-1747.2002.01806.x

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Abstract

Defolliculated is a novel spontaneous mouse mutation that maps to chromosome 11 close to the type I keratin locus. Histology shows abnormal differentiation of the sebaceous gland, with the sebocytes producing little or no sebum and undergoing abnormal cornification. The hair follicles fail to regress during catagen leading to abnormally long follicles. In contrast the hair shafts are shorter than normal, suggesting altered differentiation or proliferation of matrix cells during anagen. The shafts emerge from the follicle with cornified material still attached. The dermis contains increased numbers of immune cells, including T cells (CD4-positive), macrophages, and mast cells, at all time points examined. Complete elimination of all pelage and tail follicles occurs after two to three hair cycles, apparently by necrosis. Defolliculated may be a useful model for determining further functions of the sebaceous gland, and for understanding the regulation of catagen and hair follicle immunology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RL Dermatology
Uncontrolled Keywords: hair follicle; hair growth cycle
ISSN: 1523-1747
Last Modified: 17 Oct 2022 08:33
URI: https://orca.cardiff.ac.uk/id/eprint/428

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