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The effects of elevated endogenous GABA levels on movement-related network oscillations

Muthukumaraswamy, Suresh, Myers, J. F. M., Wilson, S. J., Nutt, D. J., Lingford-Hughes, A., Singh, Krish Devi and Hamandi, Khalid 2013. The effects of elevated endogenous GABA levels on movement-related network oscillations. Neuroimage 66 , pp. 36-41. 10.1016/j.neuroimage.2012.10.054

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Abstract

The EEG/MEG signal is generated primarily by the summation of the post-synaptic potentials of cortical principal cells. At a microcircuit level, these glutamatergic principal cells are reciprocally connected to GABAergic interneurons and cortical oscillations are thought to be dependent on the balance of excitation and inhibition between these cell types. To investigate the dependence of movement-related cortical oscillations on excitation–inhibition balance, we pharmacologically manipulated the GABA system using tiagabine, which blocks GABA Transporter 1(GAT-1), the GABA uptake transporter and increases endogenous GABA activity. In a blinded, placebo-controlled, crossover design, in 15 healthy participants we administered either 15 mg of tiagabine or a placebo. We recorded whole-head magnetoencephalograms, while the participants performed a movement task, prior to, one hour post, three hour post and five hour post tiagabine ingestion. Using time-frequency analysis of beamformer source reconstructions, we quantified the baseline level of beta activity (15–30 Hz), the post-movement beta rebound (PMBR), beta event-related desynchronisation (beta-ERD) and movement-related gamma synchronisation (MRGS) (60–90 Hz). Our results demonstrated that tiagabine, and hence elevated endogenous GABA levels causes, an elevation of baseline beta power, enhanced beta-ERD and reduced PMBR, but no modulation of MRGS. Comparing our results to recent literature (Hall et al., 2011) we suggest that beta-ERD may be a GABAA receptor mediated process while PMBR may be GABAB receptor mediated.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Uncontrolled Keywords: Magnetoencephalography; GABA; Tiagabine; Beta rhythm; Event-related desynchronisation; Gamma oscillations; Motor cortex
Publisher: Elsevier
ISSN: 1053-8119
Last Modified: 11 Sep 2019 21:27
URI: http://orca-mwe.cf.ac.uk/id/eprint/42289

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