The molecular determinants of CD8 co-receptor function

Cole, David, Laugel, Bruno Frederic, Clement, Mathew, Price, David, Wooldridge, Linda and Sewell, Andrew K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

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Abstract

CD8+ T cells respond to signals mediated through a specific interaction between the T-cell receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic α1 and α2 helices of an MHC class I (MHCI) molecule. The CD8 glycoprotein ‘co-receives’ antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 million-fold. In recent years, a number of structural and biophysical investigations have shed light on the role of the CD8 co-receptor during T-cell antigen recognition. Here, we provide a collated resource for these data, and discuss how the structural and biophysical parameters governing CD8 co-receptor function further our understanding of T-cell cross-reactivity and the productive engagement of low-affinity antigenic ligands.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Uncontrolled Keywords:	CD8, co-receptor, biophysics, crystal structure, peptide–major histocompatibility complex, T-cell activation, T-cell receptor
Publisher:	Wiley Blackwell
ISSN:	0019-2805
Last Modified:	05 Jun 2017 03:46
URI:	http://orca-mwe.cf.ac.uk/id/eprint/42122

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