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Proteoglycan metabolism, cell death and Kashin-Beck Disease

Li, Siyuan, Cao, Junling, Caterson, Bruce and Hughes, Clare Elizabeth 2012. Proteoglycan metabolism, cell death and Kashin-Beck Disease. Glycoconjugate Journal 29 (5-6) , pp. 241-248. 10.1007/s10719-012-9421-2

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Abstract

Kashin-Beck Disease (KBD) is an endemic, chronic and degenerative osteoarthropathy principally occurring in children. The characteristic pathological change of KBD is chondrocyte necrosis in hyaline articular cartilage. Proteoglycans are one of the major components in the extracellular matrix of articular cartilage, and disrupted proteoglycan metabolism and loss of proteoglycans in articular cartilage from KBD patients has been observed. In this mini-review, we discuss the close relationship between chondrocyte death including necrosis and loss of proteoglycan, and its potential mechanism during KBD onset and development, which may provide new clues for KBD research.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Uncontrolled Keywords: Kashin-Beck Disease ; Proteoglycan ; Chondrocyte ; Necrosis ; Apoptosis ; Oxidative stress
Publisher: Springer Verlag
ISSN: 0282-0080
Last Modified: 04 Jun 2017 04:37
URI: http://orca-mwe.cf.ac.uk/id/eprint/41855

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