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Analysis of gait and balance through a single triaxial accelerometer in presymptomatic and symptomatic Huntington's disease

Dalton, Anthony, Khalil, Hanan, Busse, Monica, Rosser, Anne Elizabeth, Van Deursen, Robert William Martin and ÓLaighin, Gearóid 2013. Analysis of gait and balance through a single triaxial accelerometer in presymptomatic and symptomatic Huntington's disease. Gait & Posture 37 (1) , pp. 49-64. 10.1016/j.gaitpost.2012.05.028

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Abstract

Purpose To investigate the capacity of a single triaxial accelerometer sensor in detecting gait and balance impairments in pre-manifest and manifest Huntington's disease (HD) subjects. Methods Fourteen manifest HD (MHD) (age: 51.83 ± 14.8), ten pre-manifest HD (PHD) (age: 44.8 ± 11.7) and ten healthy subjects (HLY) (age: 56.4 ± 10.9) were recruited. The sensor was attached to the upper sternum as subjects completed gait and Romberg balance tests. An inverted pendulum model of the body's centre of mass and an unbiased autocorrelation procedure were employed to derive gait parameters from the triaxial accelerometer signal. The accuracy of the gait measurements was compared to those recorded by a computerized walkway. Results Strong agreement was seen between the sensor and the walkway; cadence (ICC = 0.95, CI = [0.75, 0.97]), velocity (ICC = 0.94, CI = [0.75, 0.97]) and step length (ICC = 0.89, CI = [0.77, 0.95]). Sensor derived velocity was significantly higher in HLY (p < 0.001) and PHD (p < 0.005) when compared to MHD. Step and stride length was significantly longer in HLY (p < 0.05) and PHD (p < 0.001) when compared to MHD. Significant differences between subject groups across all four balance tasks (p < 0.001) were found. Conclusion An accelerometer based sensor may be an effective means of differentiating between pre-manifest and manifest Huntington's disease subjects.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Huntington's disease; Accelerometry; Gait; Balance
Publisher: Elsevier
ISSN: 0966-6362
Last Modified: 29 Jul 2016 15:28
URI: http://orca-mwe.cf.ac.uk/id/eprint/41736

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