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Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity

Prata, Diana P., Kanaan, Richard A., Barker, Gareth J., Shergill, Sukhwinder, Woolley, James, Georgieva, Lyudmila, Picchioni, Marco M., Kravariti, Eugenia, Walshe, Muriel, Allin, Matt, Toulopoulou, Timothea, Bramon, Elvira, McDonald, Colm, Giampietro, Vincent, Murray, Robin M., Brammer, Michael, O'Donovan, Michael Conlon and McGuire, Philip 2013. Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity. Human Brain Mapping 34 (9) , pp. 2025-2031. 10.1002/hbm.22045

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Abstract

The oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: fractional anisotropy; diffusion tensor imaging; genetics; schizophrenia; myelin
Publisher: Wiley
ISSN: 1065-9471
Last Modified: 13 Oct 2017 22:10
URI: http://orca-mwe.cf.ac.uk/id/eprint/41556

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