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Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa

Okoro, Chinyere K., Kingsley, Robert A., Connor, Thomas Richard, Harris, Simon R., Parry, Christopher M., Al-Mashhadani, Manar N., Kariuki, Samuel, Msefula, Chisomo L., Gordon, Melita A., de Pinna, Elizabeth, Wain, John, Heyderman, Robert S., Obaro, Stephen, Alonso, Pedro L., Mandomando, Inacio, MacLennan, Calman A., Tapia, Milagritos D., Levine, Myron M., Tennant, Sharon M., Parkhill, Julian and Dougan, Gordon 2012. Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa. Nature Genetics 44 (11) , pp. 1215-1221. 10.1038/ng.2423

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Abstract

A highly invasive form of non-typhoidal Salmonella (iNTS) disease has recently been documented in many countries in sub-Saharan Africa. The most common Salmonella enterica serovar causing this disease is Typhimurium (Salmonella Typhimurium). We applied whole-genome sequence–based phylogenetic methods to define the population structure of sub-Saharan African invasive Salmonella Typhimurium isolates and compared these to global Salmonella Typhimurium populations. Notably, the vast majority of sub-Saharan invasive Salmonella Typhimurium isolates fell within two closely related, highly clustered phylogenetic lineages that we estimate emerged independently ~52 and ~35 years ago in close temporal association with the current HIV pandemic. Clonal replacement of isolates from lineage I by those from lineage II was potentially influenced by the use of chloramphenicol for the treatment of iNTS disease. Our analysis suggests that iNTS disease is in part an epidemic in sub-Saharan Africa caused by highly related Salmonella Typhimurium lineages that may have occupied new niches associated with a compromised human population and antibiotic treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Subjects: D History General and Old World > DT Africa
Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 04 Jun 2017 04:37
URI: http://orca-mwe.cf.ac.uk/id/eprint/41533

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