Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?

Riganti, Chiara, Massaia, Massimo, Davey, Martin S. and Eberl, Matthias 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators? European Journal of Immunology 42 (7) , pp. 1668-1676. 10.1002/eji.201242492

Full text not available from this repository.

Abstract

Upon receiving the Nobel Prize in Physiology or Medicine in 1987, Susumu Tonegawa referred to the then recent discovery of the γδ T-cell receptor and stated that “while the function of the T cells bearing this receptor is currently unknown ( . . . ) these T cells may be involved in an entirely new aspect of immunity”. [Tonegawa, S., Scand. J. Immunol. 1993. 38: 303–319]. Twenty-five years of intense research later this ambivalent view still holds true. Immunologists now appreciate that γδ T cells indeed represent a highly intriguing “new aspect of immunity” that is unique and distinct from conventional lymphocytes, yet even scientists in the field still struggle to understand the molecular basis of γδ T-cell responses, especially with respect to the enigmaticmode of antigen recognition. Here, we portray the peculiar responsiveness of human Vγ9/Vδ2 T cells to microorganisms, tumor cells and aminobisphosphonates, in an attempt to integrate the corresponding — and at times confusing — findings into a “theory of everything” that may help explain how such diverse stimuli result in similar γδ T-cell responses via the recognition of soluble low molecular weight phosphoantigens.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > R Medicine (General)
Uncontrolled Keywords: Antigen presentation; Cancer immunotherapy; γδ T cells; Microbial infections; T-cell receptor
Publisher: John Wiley & Sons
ISSN: 0014-2980
Last Modified: 11 Sep 2020 08:39
URI: http://orca-mwe.cf.ac.uk/id/eprint/41458

Citation Data

Cited 37 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item